Leukocyte Telomere Length and Age at Menopause
نویسندگان
چکیده
منابع مشابه
Leukocyte telomere length dynamics in women and men: menopause vs age effects.
BACKGROUND A longer leukocyte telomere length (LTL) in women than men has been attributed to a slow rate of LTL attrition in women, perhaps due to high estrogen exposure during the premenopausal period. METHODS To test this premise we performed a longitudinal study (an average follow-up of 12 years) in a subset of the population-based Danish National Twin Registry. Participants consisted of 4...
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Both leukocyte telomere length (LTL) and DNA methylation age are strongly associated with chronological age. One measure of DNA methylation age─ the extrinsic epigenetic age acceleration (EEAA)─ is highly predictive of all-cause mortality. We examined the relation between LTL and EEAA. LTL was measured by Southern blots and leukocyte DNA methylation was determined using Illumina Infinium HumanM...
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In culture, replicating human somatic cells display progressive telomere shortening. Ultimately, such cells either undergo apoptosis or enter a state of replicative senescence that is triggered by critically shortened telomeres. Accordingly, telomere length is an index of both the replicative history and the replicative potential of human somatic cells in culture (1). Most replicating human som...
متن کاملMenopause modifies the association of leukocyte telomere length with insulin resistance and inflammation.
CONTEXT Leukocyte telomere length is inversely correlated with age, insulin resistance, serum leptin, and smoking. OBJECTIVE We explored whether menopausal status modifies the relations between leukocyte telomere length and insulin resistance. In addition, we examined the effect of menopause on the relation between leukocyte telomere length and C-reactive protein (CRP), an index of inflammati...
متن کاملOffspring's Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm
Leukocyte telomere length (LTL) is a complex genetic trait. It shortens with age and is associated with a host of aging-related disorders. Recent studies have observed that offspring of older fathers have longer LTLs. We explored the relation between paternal age and offspring's LTLs in 4 different cohorts. Moreover, we examined the potential cause of the paternal age on offspring's LTL by deli...
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ژورنال
عنوان ژورنال: Epidemiology
سال: 2014
ISSN: 1044-3983
DOI: 10.1097/ede.0000000000000017